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For instance, for inflammatory pathways, blocking the expression of G6PD impaired pro-inflammatory cytokine expression and lipid accumulation in LPS-activated DCs ( de novo lipid synthesis, the loss of G6PD function also led to impaired NOS2 activity in Ms activated by LPS (61) or by IFN- and infected by Trypanosoma cruzi (62)

Chemi Ed

E., Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases, Physiological Reviews 94, no

They have a wide range of subcellular localization: SOD1 is located in the cytoplasm, while SOD2 (MnSOD) is found in the mitochondria, and SOD3 (ECSOD) is distributed in the extracellular matrix [66]